Smoke N' Science

Cannabis genetics have truly gone wild with new strains emerging every day. On  this episode of Smoke N' Science we break down Cannabis genetics with  expert Dr. Anna Schwabe, PhD., also known as "Dr. Annabis". Anna is a  passionate researcher, educator, and cannabis enthusiast. You may have  heard of "pheno-hunting," but what is a phenotype? And what changes in  the plant's genetics lead to different effects and varieties of the  plant? Answers to this and more on this episode!

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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On this episode of Smoke N' Science the Smokenol™ team dives into practical application of CBD. What types of CBD products exist, what dose are people typically taking, and why are so many people finding benefits from taking CBD products. We have found many benefits of taking CBD daily but finding the optimal dose and products can be difficult. Our team will share what has worked best for us and answer some common questions regarding CBD.  If you're looking to try a new CBD product, we produce unique CBD topicals and a tincture that our customers say is more effective than other CBD products, check them out at ProfoundNaturals.com. 

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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On this episode of Smoke N' Science, Riley and Miyabe talk with Dr. Jahan Marcu, PhD an expert in the endocannabinoid system and Cannabis policy. The three dive into a variety of subjects including the many uses of CBD, synthetic THC isomers (D8-THC, D10-THC, HHC, etc.), and cannabis research and education. Regulation is a challenge for the cannabis industry, especially with the legal landscape differing with each state. Join us as we discuss the many unknowns, both positive and negative, of the every-changing industry.

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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This extra credit episode dives deeper into the science of smoke. We discuss some chemical changes that occur during the smoking process as well as discuss the major differences between smoking, dry herb vaping, and concentrate vaping. All of these cannabis consumption methods have one thing in common and that is heat. Different levels of heat introduced to the products will result in changes to the chemistry that is entering your body! Not everyone prefers the feeling of smoking, and we encourage all users to explore different consumption methods to see what works best for you. As always, thanks for listening! If you want to try our hemp smoke extract products, which have this changed chemistry, find them at ProfoundNaturals.com.

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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New episode on our favorite topic! Part of breaking the stigma of cannabis requires breaking the stigma of smoking. While we do not deny the negative side effects linked to smoking, we also believe there are unexplored advantages, specifically for cannabis. Some of us prefer the effects of smoked cannabis which actually makes smoking a more therapeutic option for a specific population. Heat transformation is significant and a major part of the science behind the unique effects of smoking. This changes the overall experience of cannabis in a way that we can't yet fully explain, but in this episode we take a shot at it!

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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A bit more about our main takeaways from our chat with Dr. Callie Seaman on cannabis and epilepsy. We take a deeper look into Epidiolex, the CBD pharmaceutical that is prescribed for epilepsy and the possible molecular mechanisms that underlie the effects. We also talk about chemodiversity which is our favorite part of the what the cannabis plant has to offer therapeutically. Next week we're covering our favorite topic: the science o' smoke!

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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Epilepsy is a neurological disorder that causes recurrent, unprovoked seizures. While there are pharmaceutical medications that treat epilepsy, not everyone responds well to them, and cannabis has been shown to have huge therapeutic potential in reducing or completely stopping seizures. We are thrilled to be joined in this episode by Dr. Callie Seaman, PhD a cannabis scientist with epilepsy who shares our love for this amazing plant and our outlook on the incredible potential of the unknown in the universe!

Disclaimer: Everything in this podcast is the opinion of the hosts and those interviewed; this is not medical advice.

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Our "extra credit" episodes will always be between full-length episodes and aim to further solidify the main takeaways from the previous episode by providing detailed information on the topic. It's always helpful to hear something described more than once, and that's certainly the case when it comes to complex topics like receptors. This episode is a deep dive into receptors and so if you're having trouble with, it may be helpful to re-listen to the previous episode. As usual, please send us any questions!

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Receptors are how your body talks to itself and to the rest of the world. We could not function without receptors and this episode focuses on the CB1 and CB2 receptors, which are the main receptors in the endocannabinoid system that interact with the active molecules in cannabis. This episode will have you thinking about your CB1 receptors in a new light that just might change the way you enjoy your cannabis! We'll also go into other substances and how Cannabis use can be a strategy for harm reduction (begins at the 51min marker).

Disclaimer: anything discussed on this podcast is not medical advice; this podcast is hosted by Cannabis scientists and consumers sharing their personal thoughts and opinions with the community.

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Welcome to season 3 with the team that is literally "smokenol day". This episode is a lightning round of the very best science bits from the rest of the season. Get a taste for what's to come - this season is going to be bigger and better with "extra credit" and facilitated discussions. Starting off with the most important receptors in the brain/body all the way to explaining how complex cannabis products can affect them, this season will help guide you to new depths in your cannabis understanding!

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Disclaimer: anything discussed on this podcast is not medical advice; this podcast is hosted by Cannabis scientists and consumers sharing their personal thoughts and opinions with the community.

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Try Our Products: www.profoundnaturals.com

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Cannabis topicals can be a helpful tool to improve quality of life by delivering a high concentration of active molecules directly on the skin. Our skin is the largest organ in the body and it is covered in CB1 receptors! Our team loves topicals and this episode is dedicated to explaining exactly why they can be so useful!

Disclaimer: anything discussed on this podcast is not medical advice; this podcast is hosted by Cannabis scientists and consumers sharing their personal thoughts and opinions with the community.

JAMA Sunscreen Paper: https://pubmed.ncbi.nlm.nih.gov/31961417/

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This week we have special guest Murphy Murri on the podcast! Murphy is an expert in Cannabis extraction and an educator in the Cannabis community. On this episode we talk about ways to get into the Cannabis industry, diving into some niche language used to describe Cannabis products, and hash, what it is and how it’s made (along with many other topics as always)! Thanks for listening!

Disclaimer: anything discussed on this podcast is not medical advice; this podcast is hosted by Cannabis scientists and consumers sharing their personal thoughts and opinions with the community.

Hash fight: @hashfight

Sano Gardens: @sanogardens

Murphy Instagram: @murphymurri

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Riley and Miyabe talk with Dr. Gordon Walker, also known as FascinatedbyFungi on social media. The three scientists talk about how different components of nature can be healing, how both mushrooms and Cannabis help us understand and appreciate the natural world and discuss censorship issues on social media while educating about natural products.

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Disclaimer: This is not medical advice; this podcast is hosted by cannabis scientists and consumers sharing their thoughts with the community.

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The most popular method for using cannabis is smoking flower; it's also the most ancient. Flower is amazing and in this episode team smokenol explains why we are so into researching smoking flower. We also take a big picture look at pharmacology, the study of drugs in the body. Whether you know it or not, pharmacology is a central part of your life. So if you've always wondered why certain strains hit different, come hang out with us in this team smokenol smoke n' science sesh!

Disclaimer: This is not medical advice; this podcast is hosted by cannabis scientists and consumers sharing their thoughts with the community.

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Andy's Trichomes: www.instagram.com/p/CbsypfwOU8H/

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Every legal cannabis purchase goes through rigorous testing before reaching the shelves to ensure the product is safe and up to standard. On this episode of Smoke n' Science, Riley and Miyabe speak with Dr. Amber Wise, PhD the scientific director of Medicine Creek Analytics in Washington State and co-chair of programming for the American Chemical Society's Cannabis Subdivision. Amber also does research, this episode dives into a brief overview of testing and where the industry is at with quality control.

Disclaimer: This is not medical advice; this podcast is hosted by cannabis scientists and consumers sharing their thoughts with the community.

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Amber's Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264932/

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Find Amber: https://www.instagram.com/medicine_creek_analytics/

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We've all had difficult conversations about cannabis. Whether it's a friend, family member, or a healthcare provider, it can be demoralizing to feel invalidated and frustrating if you're struggling to find the right words. Many people still have a negative bias about the plant, which isn’t their fault as there’s been a lot of propaganda advocating against it over the years. On this episode of Smoke N' Science, we talk to Shango Los, host of Shaping Fire and expert at cannabis communication. Together, we’re going to share some difficulties we’ve had and some tricks we use to break it all down and hopefully help change people's minds!

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Find Shango: instagram.com/shapingfire - instagram.com/shangolos

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This episode is dedicated to our all of our listeners who are patients first, like us. Your support has been amazing and inspired us to continue to make a bigger and better season 2. In this special BONUS episode, we share our stories and why we are so passionate about cannabis science and education. Our second season is going to start with a bang in just two weeks! Again, we can't thank all of you enough for choosing to be a part of our community! 

*Note: All opinions expressed in this podcast are just that. We are NOT medical professionals making formal recommendations; we are just two cannabis scientists speculating about what we would and wouldn't do in theory!

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For the last episode of Smoke N’ Science in 2021, Riley and Miyabe interview Dr. Paloma Lehfeldt. Dr. Paloma is a medical doctor, and an advocate for Cannabis. The three discuss the challenges of being a Cannabis advocate in the medical space and the stigmas associated with it, what doctors learn about Cannabis in medical school, and tools she uses to educate patients on Cannabis, among other interesting topics! Thanks for all your support this year!

*Note: All opinions expressed in this podcast are just that. We are NOT medical professionals making formal recommendations; we are just two cannabis scientists speculating about what we would and wouldn't do in theory!

If you are a licensed processor who is interested in working with us contact us through the link below or at sales@smokenol.com!

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Kyoto CBD Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856203/

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In this week’s episode of Smoke N’ Science we’re going to dive into some language used to describe different cannabis varieties. There are hundreds of different Cannabis varieties that exist, and new ones are being created every day. The different types can cause very different effects on our body because they contain different molecules! The most common term to describe these types is ‘strain’ but the Cannabis industry is evolving to include newer more accurate terms, mainly chemovar and cultivar. Let’s discuss the different language we use to describe Cannabis and where we see Cannabis classification going in the future! 

*Note: All opinions expressed in this podcast are just that. We are NOT medical professionals making formal recommendations; we are just two cannabis scientists speculating about what we would and wouldn't do in theory!

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In this episode of SmokeN’Science we dive into some specific examples of chronic pain including migraines, fibromyalgia, GI issues, and endometriosis. We then discuss some ways that would be most effective for taking Cannabis as medicine depending on how quickly you want to feel the effects and where pain is located in your body! We also have a special interview with a Cannabis grower and patient, Connor V. with Frankenstein Genetics, who will discuss how Cannabis changed the trajectory of his life with smokenol inventor Andy Westerkamp. 

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Clinical Endocannabinoid Deficiency Paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576607/ 

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Connor V./Frankenstein Genetics: https://www.frankensteingenetics.com/ 

Hosts: instagram.com/cannabichem & instagram.com/miyabephd

On  episode 2 of Smoke N' Science we talk about pain. Pain is the number one  use for medicinal Cannabis in the United States, and this is no  accident. Cannabis can change the way pain signals are sent in our  brains and provide some much-needed relief, especially for chronic pain  sufferers! In today's episode we begin to talk about pain, what it is,  the different kinds of pain, and what's happening in our brain when we  experience pain. Join us on this journey into our endocannabinoid system  to learn more- we promise it won't be painful to listen to!

Up next: in part 2 we'll dive into individual disorders where pain plays a crucial role and the different methods of administration that can be helpful for pain!

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British Medical Journal (Cannabis & Pain Paper):  https://www.bmj.com/content/374/bmj.n2040

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Hosts: instagram.com/cannabichem & instagram.com/miyabephd

Riley and Miyabe peek under the covers of cannabis research and discuss some of the barriers to science that have contributed to the stigma. Miyabe summarizes the system in our bodies that is responsible for the effects and the medicinal benefits of Cannabis, and Riley explains why natural products that contain complex formulations have unique benefits in comparison to the traditional pharmaceutical route of a single isolated molecule. Take an inside view of Riley and Miyabe’s team chemistry and how they hope to change the status quo! Up next: the science behind cannabis and all types of pain, and how the endocannabinoid system is a key regulator by multiple mechanisms. 

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 SSRI Paper: www.cell.com/cell/pdf/S0092-8674(21)00077-5.pdf 

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Hosts: instagram.com/cannabichem & instagram.com/miyabephd