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Autism Science Foundation Weekly Science Report

Autism Science Foundation Weekly Science Report

Autism Science Foundation

The week in autism research discoveries

404 - Health Concerns Across 3 Generations
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  • 404 - Health Concerns Across 3 Generations

    Are you the grandparent, cousin, aunt, uncle, sibling, or half-sibling of someone with autism and wondered “what is the likelihood of autism in families, and the likelihood of comorbid conditions if I have a family member with autism?” Researchers at the AJ Drexel Autism Research Institute and Aarhus University in Denmark collaborated to calculate probabilities between autism in a person and dozens of other comorbid conditions in family members. They not only made the paper open to the public for everyone to read it, but they also created a publicly available data visualization tool so anyone can go on and look at specific situations of particular family relationships relating to anything from autoimmune conditions to mental health and psychiatric diagnosis. Links below for reference:



    https://pubmed.ncbi.nlm.nih.gov/39283002



    Interactive graphs: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5
    Mon, 11 Nov 2024 - 24min
  • 403 - Stigma experienced around the world

    Despite many years fighting it, families with autism still experience societal stigma. The experiences depend on many factors, summarized in the October 21st podcast. This week, Mia Kotikovski explores cultural factors involved in stigma. As examples, she explores the literature from Asia, the Middle East and the United Kingdom, how they are different, and how families cope with that stigma in different areas of the world.







    https://link.springer.com/article/10.1007/s40489-023-00373-7



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330163



    https://link.springer.com/article/10.1007/s10803-019-04218-3



    https://www.nature.com/articles/s41598-022-23978-0



    https://molecularautism.biomedcentral.com/articles/10.1186/s13229-023-00579-w



    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0261774



    https://onlinelibrary.wiley.com/doi/full/10.1002/aur.2652
    Sun, 03 Nov 2024 - 16min
  • 402 - The Importance of Model Systems

    Animal models of autism, including cell based models, have received criticism because autism is a uniquely human condition so there is no value in studying it in a model like a mouse or a cell. On the other hand, model systems have been used for decades to develop therapies for a myraid of other conditions and disorders, and produced evidence-based treatments for not just autism but conditions from ADHD to schizophrenia. So why is there so much backlash about this line of research? The ASF podcast talks to Jill Silverman at UC Davis to get some perspective.



    https://pubmed.ncbi.nlm.nih.gov/35285132



    https://www.vox.com/future-perfect/377739/autism-research-mice-lab-models
    Mon, 28 Oct 2024 - 36min
  • 401 - Where is autism stigma the worst in the world?

    This week, part 1 in cultural stigma around autism with Mia Kotikovski provides an overview of stigma, where it can come from across cultures and provides some examples of stigma in different countries. Different areas of the world are in different places in terms of their perceptions of autism, their needs for autism families, and what they perceive as their greatest difficulties. The topic is so important we broke it down into two sections. Please listen to both, it will explain a lot about autism services and supports around the world.



    https://journals.sagepub.com/doi/10.1177/1362361318823550



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8992913



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303671



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303671



    https://pubmed.ncbi.nlm.nih.gov/30248583



    https://pubmed.ncbi.nlm.nih.gov/38507392



    https://www.researchgate.net/publication/277816405_A_Cross-Cultural_Comparison_of_Knowledge_and_Stigma_Associated_with_Autism_Spectrum_Disorder_Among_College_Students_in_Lebanon_and_the_United_States?enrichId=rgreq-97b7d5f50aac4d5b124ea8295b42fdb0-XXX&enrichSource=Y292ZXJQYWdlOzI3NzgxNjQwNTtBUzoyNDI4NTI2Mzk4NDIzMDRAMTQzNDkxMTk4OTI3MA%3D%3D&el=1_x_3&_esc=publicationCoverPdf
    Sun, 20 Oct 2024 - 17min
  • 400 - Factors That Influence Heterogeity and How

    Understanding factors that make each person with autism different has been a challenge, affecting diagnosis, interventions and the way we think about autism in general. Researchers at Istituto Italiano di Tecnologia, Rovereto, Italy, used computers to see how language, intellectual ability, motor and adaptive functioning grouped individuals into different categories. It turns out there are two groups – one group that improves over time and outperforms the other group consistently even in early life. The other group continues to struggle. These factors are not autism-specific, but do influence the creation of these different groups that are different biologically as well as behaviorally. This week’s podcast is an interview with the researchers on what it means for the future of understanding what might help what person at what time in their life.



    The publication is open access and includes the model so their findings can be replicated widely: https://molecularautism.biomedcentral.com/articles/10.1186/s13229-024-00613-5
    Sun, 13 Oct 2024 - 34min
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