The Metabolic Link

Did you know that nearly 60% of the average American's diet is made up of ultra-processed foods? This staggering statistic highlights a growing public health crisis linked to rising obesity rates and chronic diseases, not only in adults but our children too.In this week’s episode of The Metabolic Link, we dive into a critical conversation with Todd Wagner, a passionate advocate for food safety and health reform. As the founder of FoodFight USA, Todd is dedicated to cleaning up America’s taint...

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here.In this journal club episode of The Metabolic Link, we explore the cutting-edge "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harr...

In our 50th episode of The Metabolic Link podcast, host Dr. Dominic D’Agostino dives deep into the fascinating world of metabolic health through an unexpected lens — bottlenose dolphins. Dr. Stephanie Venn-Watson, a veterinary epidemiologist and public health scientist, joins the show to share her groundbreaking research with the U.S. Navy’s Marine Mammal Program, where dolphins helped reveal the essential role of C15:0. C15:0 is an odd-chain saturated fatty acid that has 3-times more cellula...

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of The Metabolic Link, recorded at Metabolic Health Summit 2024, we share Dr. Jeff Volek's full presentation where he takes a deep dive into the "Keto-Adapted Phenotype" with a focus on muscle. Dr. Volek, a leading expert in low-carbohydrate and ketogenic diets, shares groundbreaking research on how ketones impact muscle function and perform...

Join Dr. Norwitz for a Live Q&A on September 10th at 12pm PT/3pm ET on The Metabolic Initiative platform! Visit this link to register, and also watch his presentation Cookies & Cholesterol Controversy inside the platform (first 7-days are free): https://membership.metabolicinitiative.com/norwitzIn this episode, Dr. Nick Norwitz returns to The Metabolic Link podcast to explore the future of personalized medicine and the evolution of metabolic health research with host, Dr. Dominic D’Ag...

Become a member of The Metabolic Initiative to access a robust bank of cutting edge metabolic health content, private ad-free podcast episodes, and earn CMEs here!More than a billion people around the world suffer from mental and neurological disorders, and the numbers are escalating rapidly. Current treatments often fail to provide relief, resulting in many patients struggling with persistent symptoms and resistance to available therapies.In this episode, we’re sharing a full presentation by...

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here!In this enlightening episode of The Metabolic Link, Dr. Dominic D'Agostino sits down with Dr. Mary Newport to delve into the world of Alzheimer's disease, discussing her pioneering work with ketogenic metabolic therapy. Dr. Newport shares her personal and inspiring journey with her husband, Steve, whose battle with early-onset Alzheimer's led her to discover the life-changing effects of MCT and...

Become a member of The Metabolic Initiative for ad-free episodes and CMEsIn this episode of The Metabolic Link, host Victoria Field interviews Dr. Deanna Kelly, a distinguished professor of psychiatry at the University of Maryland School of Medicine. Dr. Kelly is pioneering nutritional interventions to treat serious mental illness and led a groundbreaking trial on the ketogenic diet for schizophrenia, the only inpatient study of its kind in the U.S. Unfortunately, this privately funded trial ...

Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of the Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biol...

Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this interview, host Victoria Field sits down with Dr. Casey Means, a Stanford-trained physician, entrepreneur, and New York Times bestselling author of the new book Good Energy. Dr. Means shares her inspiring journey from being a head and neck surgeon to leaving traditional medicine and becoming a leading voice in the metabolic health field. They take a deep di...

Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs! Registered dietitian, Lily Nichols, RDN, CDE, is back on The Metabolic Link, this time in an intimate interview that dives into the critical links between metabolic health, perinatal nutrition, and long-term wellbeing. This episode dives deep into how nutrition during the childbearing years can affect not only mothers but their children throughout their lives.Lily, who is also a New York Times bestselling ...

Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs!Join us in this enlightening episode as we dive deep into the emerging research behind Urolithin A and its impact on mitochondrial health with Dr. Anurag Singh, a leading expert in the field and the Chief Medical Officer of Timeline.The discussion spans various facets of Urolithin A, from its origin in pomegranates and other foods to its potential in improving mitochondrial health, muscle strength, and redu...

Become a member of The Metabolic Initiative for exclusive episodes and earn CMEs! Dive into the core of nutrition science with Dr. Dominic D'Agostino and Dr. Nina Teicholz, and uncover the remarkable benefits of saturated fats, unravel the complexities of LDL cholesterol, and dig into the heated debate surrounding food addiction and ethical meat consumption. Dr. Teicholz sheds light on the misunderstood facets of dietary fats, debunking prevalent myths about cholesterol, highlighting potent...

Become a member of The Metabolic Initiative for exclusive episodes and to earn CMEsIn this episode, recorded at Metabolic Health Summit 2024, Dr. Richard Johnson dives into the groundbreaking research that has uncovered the central role of fructose in driving the epidemics of obesity, diabetes, and a wide range of other metabolic diseases.Dr. Johnson presents compelling evidence that fructose, a seemingly innocuous sugar, is in fact a key trigger for activating a powerful biological survival ...

In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significa...

The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.The d...

This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Jeff Volek, a professor at The Ohio State University. With a PhD in Kinesiology specializing in exercise and nutrition science from Penn State University, Dr. Volek has performed cutting edge research on how humans adapt to diets restricted in carbohydrates with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 300 peer-reviewed scien...

This week's episode of The Metabolic Link features a full presentation from Metabolic Health Summit 2024. Dr. Ben Bikman, professor at Brigham Young University, dives deep into the intricacies of fat and its relationship to metabolic health.This is the full presentation he delivered at Metabolic Health Summit 2024 in Clearwater Beach, Florida. In it he shares his expertise on the link between body fat, insulin resistance, and chronic diseases such as obesity and diabetes. Throughout this talk...

This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Georgia Ede, a Harvard-trained psychiatrist specializing in nutrition science and brain metabolism. With over 25 years of clinical experience, including 12 years as a college psychiatrist and nutrition consultant at Smith College and Harvard University Health Services, Dr. Ede was the first to offer students nutrition-based approaches as an alternative to psychiatric medications. She speaks internat...

In this episode of The Metabolic Link, Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field recap Metabolic Health Summit 2024, the world’s leading medical and scientific conference on metabolic health. Listen to this episode to get an inside look at the top scientific highlights and surprising moments from the perspective of the hosts who made it happen.Want to learn about all the cutting-edge research and scientific insights on metabolic health and therapy that you won’t find anywher...

We’ve just launched an extra and exciting episode of The Metabolic Link podcast! It features an eye-opening conversation between our host Dominic D’Agostino PhD, and guests Dave Feldman and Dr. Nick Norwitz, two researchers and MHS 2024 speakers spearheading investigations into the lean mass hyperresponder (LMHR) phenotype.Dave Feldman is a software engineer who became deeply interested in lipidology after seeing his cholesterol spike on a low-carb, high-fat diet. He has since performed self-...

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dominic D’Agostino and Dr. Jonathan Jun, a pulmonary critical care and sleep medicine physician at Johns Hopkins.He is an expert in the diagnosis and treatment of sleep-disordered breathing, and in the care of critically ill patients in the Medical ICU. He is a member of the Sleep Fellowship Program Evaluation and Clinical Competency Committee and provides teaching to medical students and resi...

In this episode, our co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field discuss two recent scientific papers on the metabolic effects of allulose and how blocking fructose intake may help fight cancer.The first paper examines how allulose consumption influences metabolic factors like appetite, blood sugar, and insulin sensitivity through the release of key gut hormones and effects on carbohydrate digestion and metabolism.The second paper reviews multiple lines of evidence li...

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dom D’Agostino and Chad Vanags, a successful entrepreneur who is navigating a stage 4 cancer diagnosis with courage and purpose.After being diagnosed with stage 4 lung cancer in 2022 at just 39 years old, Chad has been documenting his journey to becoming “metabolically, physically, and mentally elite” to continue pursuing his life's vision.In this wide-ranging discussion, we cover:💪 Chad's bac...

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dominic D'Agostino, PhD, and Franziska Spritzler, RD, CDE.Franziska is a registered dietitian and certified diabetes educator who specializes in low-carb and ketogenic diets. She has been following a low-carb approach for over a decade.In this episode, we cover:💡 The essential tools Franziska uses when helping clients adhere to low-carb diets💡 Managing and interpreting changes in blood work on low...

In this episode, our co-hosts Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff discuss two recent scientific papers on the potential metabolic connections to psychiatric disorders and mindfulness-based interventions.The first paper is a systematic review on the efficacy of low-carb and ketogenic diets for treating mood and anxiety disorders. They discuss the importance in defining what constitutes a low-carb or ketogenic diet in research studies. Our hosts also discuss the limited ...

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dominic D'Agostino and Dr. Kyle Gillett, a board-certified physician in family and obesity medicine who provides holistic care to his patients.He earned his medical degree at the University of Kansas School of Medicine, practices at the Gillett Health Clinic in Olathe, Kansas, and is the host of The Gillett Health Podcast. His practice focuses on preventive, integrative, and precision medicine...

This week's episode of The Metabolic Link features an eye-opening discussion between Metabolic Health Summit organizer Victoria Field and prenatal nutrition expert Lily Nichols, RDN, CDE. Lily is the author of two bestselling books - Real Food for Pregnancy and Real Food for Gestational Diabetes. Her work focuses on evidence-based, critical analysis of conventional pregnancy nutrition recommendations.In this episode, we cover:Evaluating macronutrient needs in pregnancy, including research sug...

In this week’s episode of The Metabolic Link, double board certified psychiatrist and obesity medicine physician, Dr. Shebani Sethi, takes us on a deep dive into the emerging field of metabolic psychiatry.Dr. Shebani Sethi is a psychiatrist and obesity medicine physician at Stanford University School of Medicine. She is the founding director of the Stanford Metabolic Psychiatry Clinic, where she researches dietary and pharmacological interventions to improve metabolic health and mental illnes...

This week’s episode of The Metabolic Link features an illuminating conversation between our host Dominic D’Agostino, PhD, and Dr. Abbi Hernandez, an assistant professor at the University of Alabama at Birmingham.Dr. Hernandez received her PhD from the University of Florida, where she studied age and diet related changes in neurological function and cognitive health. Her research has focused on investigating the potential of ketogenic diets and time-restricted feeding for preventing age-relate...

In this week’s episode, host Victoria Field speaks with Matt Baszucki and Dr. Iain Campbell about their lived experiences with bipolar disorder and the therapeutic effects of the ketogenic diet, potential root causes of the mental illness, and their mission to spread awareness and education around ketogenic dietary therapy as a treatment for bipolar disorder.Iain Campbell, PhD, is the Baszucki Research Fellow in Metabolic Psychiatry at the University of Edinburgh. He has a PhD in Global Healt...

In this episode, our co-hosts Victoria Field, Dominic D’Agostino, PhD, and Angela Poff, PhD, discuss two recent scientific studies that focus on the potential metabolic connections to neurodegenerative diseases.Study 1: Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s diseaseThe study delves into the molecular changes causing a neuron's transition from healthy to degenerative, as seen in sporadic Alzheimer's, which is the most prevalent form of Alz...

This week’s episode of The Metabolic Link features an in-depth conversation between our host Dominic D’Agostino, PhD, and Jeff Volek, PhD, RD, on a wide range of topics as well as questions submitted by our Twitter followers!Dr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last 25 years, he has performed translational research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applicat...

On this week’s episode of The Metabolic Link, our host and MHS Co-organizer Victoria Field interviewed Kelly Faltersack, a registered dietitian nutritionist, who specializes in treating patients with ketogenic diet therapy as an effective treatment for epilepsy and other neurological disorders.Kelly Faltersack MS, RDN, LDN, CD is a registered dietitian nutritionist at UW Health in Madison, Wisconsin. Kelly has over 10 years of experience as a registered dietitian nutritionist, and five years ...

This week’s episode of The Metabolic Link features an enlightening conversation between our host Dr. Dominic D’Agostino and Dr. Satchin Panda, PhD on the fascinating connection between time-restricted eating, circadian rhythm, and metabolic health. A leading expert in the field of circadian rhythm research, Dr. Panda is a professor at the Salk Institute for Biological Studies and a founding executive member of the Center for Circadian Biology at the University of California.Have you been hear...

This week’s episode of The Metabolic Link features an interview with Nicole Laurent, a Licensed Mental Health Counselor who helps her clients use ketogenic dietary therapy as a treatment for mental illness and neurological issues. Nicole was one of seven pioneers of Metabolic Psychiatry recognized by the Baszucki Brain Research Fund and the Milken Institute with the Metabolic Mind Award in 2022.What is Metabolic Psychiatry?Metabolic psychiatry is an emerging field that focuses on targeting an...

In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field review recent research uncovering the potential impact of high blood glucose on stroke outcomes and the positive influence of exercise on Alzheimer’s disease.An ischemic stroke happens when a blood vessel in the brain is occluded. This prevents oxygen and nutrients from reaching a region of the brain, ultimately causing some of that tissue to die. A hemorrhagic stroke occurs when...

It’s said that more than one billion individuals around the world suffer from migraines each year. A migraine isn’t your average headache. It’s often completely debilitating and may include sensitivity to light and sound, vomiting, severe pain, and other symptoms that can wreak havoc on quality of life. Despite being one of the most common neurological disorders on the planet with a high prevalence in (particularly female) young adults, many of those troubled by migraines do not receive effec...

On this episode of The Metabolic Link, we’re sitting down with Dr. Kwadwo Kyeremanteng to discuss his experience as a critical care physician during 2020, the importance of metabolic health in fighting viral infections, and how improving global metabolic health will make us more resilient against future illnesses.Dr. Kyeremanteng is an ICU doctor and intensivist at The Ottawa Hospital who seeks to increase the efficiency of medical care with cost-effectiveness, dignity, and justice in mind wh...

You won’t be surprised to hear that a night of poor sleep can affect how good you feel the next day. But did you know that disruptions in sleep quality, especially when they occur chronically, can have a major negative impact on your cognitive function, mood, and overall metabolic health?On this week’s Journal Club episode of The Metabolic Link, co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field dive into two research publications exploring how meal timing in shift workers a...

On this week’s episode of The Metabolic Link, host Dr. Dominic D’Agostino is sitting down with neuroscientist, Tommy Wood, MD, PhD, to discuss optimizing human health and cognitive function. In this interview, Dom explores a wide variety of fascinating topics with Dr. Wood. They uncover why cognitive demand may be important in preventing devastating neurological disorders like dementia, the importance of monitoring cardiovascular risk biomarkers including insulin, ApoB, homocysteine, and...

On this week’s episode of The Metabolic Link, we’re sitting down with OBGYN and Ketogenic Metabolic Therapy Expert, Jaime Seeman, MD, to discuss the importance of metabolic health through a woman's life stages. In this interview, we explore how and why a woman might want to optimize their metabolic health in their fertile years, into menopause, and beyond. We also uncover the specific issues women can face along the way, the potential of metabolic therapy in improving hormone funct...

On this week’s Journal Club episode of The Metabolic Link, co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field discuss two seemingly conflicting research studies exploring the effects of ketosis on muscle health in models of atrophy.Atrophy refers to the wasting of a body tissue or organ that occurs due to the degeneration of cells. Atrophy of vital tissues such as the skeletal muscle occurs in numerous pathological catabolic conditions, such as in cancer cachexia, motor neur...

On this week’s episode of The Metabolic Link, Dr. Dominic D’Agostino is sitting down with world-renowned metabolic scientist, Ben Bikman, PhD, to explore the ins and outs of insulin resistance, Type 2 Diabetes Mellitus (T2DM), and ways to manage, and even reverse, both.In this discussion, Dr. Bikman makes a case for why testing fasting insulin should be a part of the diagnostic and treatment equation when addressing T2DM, the difference between pathological and physiological insulin resistanc...

In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field review recent research exploring the use of ketogenic metabolic therapy in Parkinson’s Disease and Mental Illness.The first study discussed investigates the effects of a ketogenic diet applied prior to versus after the onset of Parkinson’s disease in an animal model. Parkinson’s disease is a highly prevalent disease, with over 6 million people worldwide who suffer from it. We und...

On this week’s episode of The Metabolic Link, we’re sitting down with Oncology Dietitian, L.J. Amaral for a fascinating conversation that explores implementing metabolic therapy, such as the ketogenic diet, within oncology. In this episode, we dive into why she started using metabolic therapy for cancer, how she implements it with patients at Cedars-Sinai, and the kind of results she’s seen in using it. We also cover some of the most difficult obstacles in starting a ketogenic diet in the fac...

On this week’s episode of The Metabolic Link, we’re sitting down with world-renowned Fasting and Longevity Researcher, Valter Longo, PhD, to explore a variety of topics related to metabolic health including the impact of protein consumption on longevity, the latest research on the fasting mimicking diet in diabetes and Alzheimer’s, the future of metabolic therapies, and how both our host of The Metabolic Link, Dr. Dominic D'Agostino, and Dr. Longo utilize fasting and approach healthy eating i...

On this week's episode of The Metabolic Link, we’re sitting down with Longevity and Epigenetics Researcher, Lucia Aronica, PhD, to explore the science behind how our DNA and diet dance together to determine our metabolic health. We also dive into how nutrition affects our epigenetics, how an individual’s genetic makeup influences which diet is most suitable for them, and what biomarkers can be utilized to assess response to diet. Dr. Lucia Aronica, Ph.D., is Lecturer at Stanford Universi...

In this week’s Journal Club episode of The Metabolic Link, hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field explore metabolic therapy for cancer and why some researchers believe that the altered metabolism that drives tumor progression might be successfully targeted with novel metabolic focused approaches such as the ketogenic diet. They specifically review and evaluate a 2022 case study detailing the use of a calorie restricted ketogenic diet complementary to standard of car...

On this week’s episode of The Metabolic Link, host Dr. Dominic D’Agostino sits down with Dr. Molly Maloof to explore the importance of metabolic health for women and how to optimize it. They dive into biotechnology, fasting, the ketogenic diet, hormone testing, and the importance of social connection for metabolic and mental wellbeing. They also dive into a common struggle many women face: trying to lose weight or improve health while under a lot of stress… and Dr. Maloof even shares her pers...

On today's episode of The Metabolic Link podcast, we're sitting down with Harvard Psychiatrist, Christopher Palmer, MD, to explore the common thread between brain energy metabolism and mental health. In this intimate interview, we dive into how Dr. Palmer became a pioneer in the field of metabolic psychiatry, the role of metabolic therapy in mental health and how its impacted the lives of his patients, and much more. Dr. Palmer is a psychiatrist and researcher working at the interface of meta...

Welcome to The Metabolic Link! A podcast that explores the common thread of metabolism in health and disease. In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field dive into the central link of metabolism that exists between most chronic illnesses, and how research in this growing field is unveiling new, promising strategies to optimize health and delay, prevent, or treat the development of disease.In every episode of The Metabolic ...